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Comment
. 2015 Feb 9;27(2):151-3.
doi: 10.1016/j.ccell.2015.01.005.

14-3-3ζ turns TGF-β to the dark side

Peter ten Dijke  1 , Hans van Dam  2
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14-3-3ζ turns TGF-β to the dark side

Peter ten Dijke et al. Cancer Cell. .
Free article

Abstract

TGF-β/SMAD signaling has long been known to exhibit a dual role in cancer, questioning what determines its context-dependent functions. In this issue of Cancer Cell, Xu and colleagues describe a critical role of the adaptor protein 14-3-3ζ in modulating SMAD activities by changing its interaction partners during breast cancer progression.

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