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. 2015 Mar;9(3):235-7; quiz 238.
doi: 10.1016/j.jash.2015.01.005. Epub 2015 Jan 13.

Basic science: hypertensive target organ damage

Anil K Bidani, Karen A Griffin

Basic science: hypertensive target organ damage

Anil K Bidani et al. J Am Soc Hypertens. 2015 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
Fig. 1a. The differing BP thresholds and slopes of the relationship between BP and renal damage in patients with uncomplicated hypertension (benign and malignant nephrosclerosis) and those with diabetic and non-diabetic CKD. Fig. 1b. Illustration of the spectrum of pressure/flow relationships in the renal vascular bed in hypertension. Pattern A represents the normal renal autoregulatory responses observed in uncomplicated hypertension and shows the constancy of renal blood flow (RBF) despite BP changes within the autoregulatory range. Pattern B indicates the ambient renal vasodilation but preserved autoregulation after uninephrectomy. Pattern C illustrates the impaired RBF autoregulatory responses observed in the 5/6 renal ablation model. Pattern D shows the complete loss of renal autoregulation in 5/6 renal ablated rats treated with dihydropyridine CCBs. Although RBF is depicted as the dependent variable, the same relationships are expected to obtain for glomerular pressures, given that the autoregulatory resistance changes are confined to the preglomerular vasculature.
Fig. 1
Fig. 1
Fig. 1a. The differing BP thresholds and slopes of the relationship between BP and renal damage in patients with uncomplicated hypertension (benign and malignant nephrosclerosis) and those with diabetic and non-diabetic CKD. Fig. 1b. Illustration of the spectrum of pressure/flow relationships in the renal vascular bed in hypertension. Pattern A represents the normal renal autoregulatory responses observed in uncomplicated hypertension and shows the constancy of renal blood flow (RBF) despite BP changes within the autoregulatory range. Pattern B indicates the ambient renal vasodilation but preserved autoregulation after uninephrectomy. Pattern C illustrates the impaired RBF autoregulatory responses observed in the 5/6 renal ablation model. Pattern D shows the complete loss of renal autoregulation in 5/6 renal ablated rats treated with dihydropyridine CCBs. Although RBF is depicted as the dependent variable, the same relationships are expected to obtain for glomerular pressures, given that the autoregulatory resistance changes are confined to the preglomerular vasculature.
See this image and copyright information in PMC

References

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