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Review
. 2015 Aug;64(8):1314-26.
doi: 10.1136/gutjnl-2014-308943. Epub 2015 Feb 10.

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure

Mirjam B Zeisel  1 , Julie Lucifora  2 , William S Mason  3 , Camille Sureau  4 , Jürgen Beck  5 , Massimo Levrero  6 , Michael Kann  7 , Percy A Knolle  8 , Monsef Benkirane  9 , David Durantel  2 , Marie-Louise Michel  10 , Brigitte Autran  11 , François-Loïc Cosset  12 , Hélène Strick-Marchand  13 , Christian Trépo  14 , Jia-Horng Kao  15 , Fabrice Carrat  16 , Karine Lacombe  16 , Raymond F Schinazi  17 , Françoise Barré-Sinoussi  18 , Jean-François Delfraissy  19 , Fabien Zoulim  14
Affiliations
Review

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure

Mirjam B Zeisel et al. Gut. 2015 Aug.

Abstract

HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and treatments are available, to date there is no reliable cure for the >240 million individuals that are chronically infected worldwide. Current treatments can only achieve viral suppression, and lifelong therapy is needed in the majority of infected persons. In the framework of the French National Agency for Research on AIDS and Viral Hepatitis 'HBV Cure' programme, a scientific workshop was held in Paris in June 2014 to define the state-of-the-art and unanswered questions regarding HBV pathobiology, and to develop a concerted strategy towards an HBV cure. This review summarises our current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.

Keywords: HEPATITIS B.

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