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. 2014 Dec 5;3(1):26.
doi: 10.1186/2047-9158-3-26. eCollection 2014.

Prevalence of wearing-off and dyskinesia among the patients with Parkinson's disease on levodopa therapy: a multi-center registry survey in mainland China

Wei Chen #  1 , Qin Xiao #  1 , Ming Shao  2 , Tao Feng  3 , Wei-Guo Liu  4 , Xiao-Guang Luo  5 , Xiao-Chun Chen  6 , An-Mu Xie  7 , Chun-Feng Liu  8 , Zhen-Guo Liu  9 , Yi-Ming Liu  10 , Jian Wang  11 , Sheng-Di Chen  1
Affiliations

Prevalence of wearing-off and dyskinesia among the patients with Parkinson's disease on levodopa therapy: a multi-center registry survey in mainland China

Wei Chen et al. Transl Neurodegener. .

Abstract

Objective: Chronic levodopa (L-dopa) treatment in Parkinson's disease (PD) is often associated with the development of motor complications, but the corresponding epidemiological data is rare in Chinese PD patients. The present survey was to investigate the prevalence rate of wearing-off (WO) and dyskinesia among the patients with PD in China.

Methods: From May 2012 to October 2012, a 3-step registry survey for wearing off (WO) and dyskinesia patients with PD receiving levodopa therapy was performed simultaneously at 28 movement disorders clinics in China.

Results: There were 1,558 PD patients fulfilling the inclusion criteria. Among them, 1,051 had at least one positive response of 9-item wearing off questionnaire (WOQ-9), 724 and 160 patients were finally diagnosed with WO and dyskinesia by movement disorders specialists, respectively. The overall prevalence rates of WO and dyskinesia were 46.5% (95% CI 44.0% - 48.9%) and 10.3% (95% CI 8.8% - 11.8%), respectively. The mean score of WOQ-9 for those with WO was 3.8 (SD = 1.8), with movement slowness being the most common motor symptoms and pain/aching being the most common non-motor symptoms. Better improvement of motor symptoms (n = 354, 87.8%) and long-term disease control and drug selection (n = 288, 71.5%) were the two most frequently considered factors when movement disorders specialists adjusted therapeutic strategies for patients with WO.

Conclusions: This survey provided the first multi-center epidemiological data of motor complications among PD patients on L-dopa therapy from mainland China. WO prevalence rate among Chinese PD patients was in line with, while dyskinesia prevalence rate was lower than previous reports from other Countries.

Keywords: Dyskinesia; Epidemiology; Parkinson’s disease; Wearing-off.

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Figures

Figure 1
Figure 1
Flow chart of patients with WO through the survey. WOQ-9, the 9-item wearing off questionnaire; WO, wearing-off.
Figure 2
Figure 2
Percentage of PD with WO and dyskinesia stratified by L-dopa therapy duration (n = 1488).
Figure 3
Figure 3
Frequency of motor and non-motor WO symptoms with respect to WOQ-9 among WO patients ( n = 724).
See this image and copyright information in PMC

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