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. 2014 Dec;4(Suppl 2):479-81.
doi: 10.5681/apb.2014.071. Epub 2014 Dec 31.

Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages

Sheyda Shaafi  1 , Javad Mahmoudi  1 , Ali Pashapour  1 , Mehdi Farhoudi  1 , Saeed Sadigh-Eteghad  1 , Hossein Akbari  1
Affiliations

Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages

Sheyda Shaafi et al. Adv Pharm Bull. 2014 Dec.

Abstract

Ischemic stroke is a leading cause of death and disability in the world. Many mechanisms contribute in cell death in ischemic stroke. Ketogenic diet which has been successfully used in the drug-resistant epilepsy has been shown to be effective in many other neurologic disorders. The mechanisms underlying of its effects are not well studied, but it seems that its neuroprotective ability is mediated at least through alleviation of excitotoxicity, oxidative stress and apoptosis events. On the basis of these mechanisms, it is postulated that ketogenic diet could provide benefits to treatment of cerebral ischemic injuries.

Keywords: Apoptosis; Excitotoxicity; Ketogenic diet; Oxidative stress; Stroke.

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