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Review
. 2015 Jan-Feb;90(1):62-73.
doi: 10.1590/abd1806-4841.20152890.

Localized scleroderma: clinical spectrum and therapeutic update

Mariana Figueiroa Careta  1 , Ricardo Romiti  1
Affiliations
Review

Localized scleroderma: clinical spectrum and therapeutic update

Mariana Figueiroa Careta et al. An Bras Dermatol. 2015 Jan-Feb.

Abstract

Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is confined to the skin and/or underlying tissues. Localized scleroderma is a rare disease of unknown etiology. Recent studies show that the localized form may affect internal organs and have variable morbidity. Treatment should be started very early, before complications occur due to the high morbidity of localized scleroderma. In this review, we report the most important aspects and particularities in the treatment of patients diagnosed with localized scleroderma.

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Conflict of interest statement

Conflict of interest: None

Figures

FIGURE 1
FIGURE 1
Plaque morphea lesion involving the trunk
FIGURE 2
FIGURE 2
Patient with deep morphea involving the right lower limb
FIGURE 3
FIGURE 3
A. Patient with a linear scleroderma lesion (trilinear) on the forehead; B. Scheme of Blaschko´s lines
FIGURE 4
FIGURE 4
Patient with LScs
FIGURE 5
FIGURE 5
Patient with PFH
FIGURE 6
FIGURE 6
Histology of late-phase scleroderma
See this image and copyright information in PMC

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