Minimizing antibiotic exposure in the ICU: in search of the optimal strategy
- PMID: 25672663
- PMCID: PMC4330599
- DOI: 10.1186/s13054-014-0613-y
Minimizing antibiotic exposure in the ICU: in search of the optimal strategy
Abstract
The current paradigm for antibiotic management in critically ill patients is to initiate broad-spectrum therapy followed by de-escalation based on microbiological results. Routine screening cultures may allow better targeting and reduce unnecessary exposure to antibiotics.
Comment on
-
Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit: a retrospective analysis.Crit Care. 2014 Jul 15;18(4):R152. doi: 10.1186/cc13990. Crit Care. 2014. PMID: 25030270 Free PMC article.
References
-
- De Bus L, Saerens L, Gadeyne B, Boelens J, Claeys G, De Waele JJ, Benoit DD, Decruyenaere J, Depuydt P. Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit: a retrospective analysis. Crit Care. 2014;18:R152. doi: 10.1186/cc13990. - DOI - PMC - PubMed
-
- Niederman MS, Craven DE, Bonten MJ, Chastre J, Craig WA, Fagon JY, Hall JB, Jacoby GA, Kollef MH, Luna CM, Mandell LA, Torres A, Wunderink RG, American Thoracic Society and Infectious Diseases Society of America Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388–416. doi: 10.1164/rccm.200405-644ST. - DOI - PubMed
-
- Depuydt P, Benoit D, Vogelaers D, Decruyenaere J, Vandijck D, Claeys G, Verschraegen G, Blot S. Systematic surveillance cultures as a tool to predict involvement of multidrug antibiotic resistant bacteria in ventilator-associated pneumonia. Intensive Care Med. 2008;34:675–682. doi: 10.1007/s00134-007-0953-z. - DOI - PubMed
-
- Luna CM, Sarquis S, Niederman MS, Sosa FA, Otaola M, Bailleau N, Vay CA, Famiglietti A, Irrazabal C, Capdevila AA. Is a strategy based on routine endotracheal cultures the best way to prescribe antibiotics in ventilator-associated pneumonia? Chest. 2013;144:63–71. doi: 10.1378/chest.12-1477. - DOI - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources