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Clinical Trial
. 1989 May;52(5):631-5.
doi: 10.1136/jnnp.52.5.631.

Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders

A Braun  1 , M M Mouradian, E Mohr, G Fabbrini, T N Chase
Affiliations
Clinical Trial

Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders

A Braun et al. J Neurol Neurosurg Psychiatry. 1989 May.

Abstract

The motor and cognitive effects of a selective D-1 dopamine receptor agonist, SKF 39393, were assessed in patients with Huntington's disease, Gilles de la Tourette's syndrome, tardive dyskinesia, and torsion dystonia, using a double-blind placebo-controlled design. Over daily doses ranging from 3.2 to 32 mg/kg and treatment intervals extending from one to seven weeks, no consistent changes could be discerned. The contribution of D-1 receptor mediated mechanisms to the pathophysiology of hyperkinetic extrapyramidal disorders remains uncertain.

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