Integration of whole-genome sequencing into infection control practices: the potential and the hurdles
- PMID: 25673795
- PMCID: PMC4365213
- DOI: 10.1128/JCM.00349-15
Integration of whole-genome sequencing into infection control practices: the potential and the hurdles
Abstract
Microbial whole-genome sequencing (WGS) is poised to transform many of the currently used approaches in medical microbiology. Recent reports on the application of WGS to understand genetic evolution and reconstruct transmission pathways have provided valuable information that will influence infection control practices. While this technology holds great promise, obstacles to full implementation remain. Two articles in this issue of the Journal of Clinical Microbiology (S. Octavia, Q. Wang, M. M. Tanaka, S. Kaur, V. Sintchenko, and R. Lan, J Clin Microbiol 53:1063-1071, 2015, doi:10.1128/JCM.03235-14, and S. J. Salipante, D. J. SenGupta, L. A. Cummings, T. A. Land, D. R. Hoogestraat, and B. T. Cookson, J Clin Microbiol 53:1072-1079, 2015, doi:10.1128/JCM.03385-14) describe the breadth of application of WGS to the field of clinical epidemiology.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Comment on
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Delineating community outbreaks of Salmonella enterica serovar Typhimurium by use of whole-genome sequencing: insights into genomic variability within an outbreak.J Clin Microbiol. 2015 Apr;53(4):1063-71. doi: 10.1128/JCM.03235-14. Epub 2015 Jan 21. J Clin Microbiol. 2015. PMID: 25609719 Free PMC article.
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Application of whole-genome sequencing for bacterial strain typing in molecular epidemiology.J Clin Microbiol. 2015 Apr;53(4):1072-9. doi: 10.1128/JCM.03385-14. Epub 2015 Jan 28. J Clin Microbiol. 2015. PMID: 25631811 Free PMC article.
References
-
- Roetzer A, Diel R, Kohl TA, Ruckert C, Nubel U, Blom J, Wirth T, Jaenicke S, Schuback S, Rusch-Gerdes S, Supply P, Kalinowski J, Niemann S. 2013. Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: a longitudinal molecular epidemiological study. PLoS Med 10:e1001387. doi:10.1371/journal.pmed.1001387. - DOI - PMC - PubMed
-
- Harris KA, Underwood A, Kenna DT, Brooks A, Kavaliunaite E, Kapatai G, Tewolde R, Aurora P, Dixon G. 1 December 2014, posting date. Whole-genome sequencing and epidemiological analysis do not provide evidence for cross-transmission of Mycobacterium abscessus in a cohort of pediatric cystic fibrosis patients. Clin Infect Dis doi:10.1093/cid/ciu967. - DOI - PMC - PubMed
-
- Köser CU, Holden MT, Ellington MJ, Cartwright EJ, Brown NM, Ogilvy-Stuart AL, Hsu LY, Chewapreecha C, Croucher NJ, Harris SR, Sanders M, Enright MC, Dougan G, Bentley SD, Parkhill J, Fraser LJ, Betley JR, Schulz-Trieglaff OB, Smith GP, Peacock SJ. 2012. Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak. N Engl J Med 366:2267–2275. doi:10.1056/NEJMoa1109910. - DOI - PMC - PubMed
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