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. 2015 Feb 2:9:217-23.
doi: 10.2147/OPTH.S75938. eCollection 2015.

Two percent ethylenediaminetetraacetic acid chelation treatment for band-shaped keratopathy, without blunt scratching after removal of the corneal epithelium

Wataru Kobayashi  1 , Shunji Yokokura  1 , Takehiro Hariya  1 , Toru Nakazawa  2
Affiliations

Two percent ethylenediaminetetraacetic acid chelation treatment for band-shaped keratopathy, without blunt scratching after removal of the corneal epithelium

Wataru Kobayashi et al. Clin Ophthalmol. .

Abstract

Background: The purpose of this study was to assess the effectiveness of 2% ethylenediaminetetraacetic acid (EDTA) for the treatment of band-shaped keratopathy.

Methods: We studied 24 eyes of 16 patients with band-shaped keratopathy who underwent EDTA chelation treatment from April 1, 2011 to December 31, 2012. We compared preoperative and 1 month postoperative logarithm of the minimum angle of resolution (logMAR) best corrected visual acuity, intraocular pressure, and corneal curvature radius (K1, horizontal meridian; K2, vertical meridian; Km, average of K1 and K2). The Mann-Whitney U-test was used to determine the significance of differences.

Results: There was a significant difference in preoperative and postoperative logMAR best corrected visual acuity (P=0.01). There were no significant differences in preoperative and postoperative intraocular pressure (P=0.24) or corneal curvature radius (K1, P=0.54; K2, P=0.49; Km, P=0.45).

Conclusion: After 2% EDTA chelation treatment, post-operative logMAR best corrected visual acuity improved significantly. Moreover, since there was no significant difference in corneal curvature radius, there was little influence on corneal surface form. We believe that the results of our 2% EDTA chelation treatment were comparable with results obtained with 3.75% EDTA chelation treatment in previous reports. Two percent EDTA chelation is an effective treatment for band-shaped keratopathy and a useful method for any institution.

Keywords: band-shaped keratopathy; cornea; ethylenediaminetetraacetic acid; phototherapeutic keratectomy.

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Figures

Figure 1
Figure 1
Surgical technique. Notes: (A) Removal of the corneal epithelium from the area of the opacity with a golf club spud. (B) Applying a fragment of MQA (surgical sponge) dipped in EDTA to the opacity. (C) Checking for any remaining opacity with a light guide. Abbreviation: EDTA, ethylenediaminetetraacetic acid.
Figure 2
Figure 2
Representative images of eyes with BSK before (A) and after (B) EDTA chelation. The patient’s symptoms resolved completely after the procedure. Abbreviations: BSK, band-shaped keratopathy; EDTA, ethylenediaminetetraacetic acid.
See this image and copyright information in PMC

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