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Case Reports
. 2014 Dec 1;7(12):9099-103.
eCollection 2014.

Epithelioid angiosarcoma of the ilium: a case report

Mingxia Chen  1 , Wei Zhang  2 , Jianli Qu  2 , Lei Li  2 , Qing Sun  3
Affiliations
Case Reports

Epithelioid angiosarcoma of the ilium: a case report

Mingxia Chen et al. Int J Clin Exp Pathol. .

Abstract

Bone epithelioid angiosarcoma (EA) is rare and characterized by large, mildly to moderately pleomorphic epithelioid cells, with abundant eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. The tumors may arise in various locations in bone and the patients may present with unifocal or multifocal osseous disease. We present a unifocal lesion case of EA of the ilium in a 62-year-old woman. A needle biopsy of the ilium was performed and first diagnosed poorly differentiated adenocarcinoma based on CKpan and CK18 immunopositivity. The tumor was treated initially with curettage followed by chemotherapy. The final diagnosis on the surgical specimen was epithelioid angiosarcoma.

Keywords: Epithelioid angiosarcoma; bone.

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Figures

Figure 1
Figure 1
A. Radiographs showing the osteolytic lesion in the right ilium. C. Computed tomography scan revealing an osteolytic lesion with ill-defined margins and extending into the proximal soft tissue. B. Magnetic resonance image revealing a cystic, destructive soft tissue lesion of the right ilium.
Figure 2
Figure 2
Histological features of epithelioid angiosarcoma of bone. (A) Epithelioid tumor cells arranged in sheets. (C) Foci of spindle-shaped tumor cells formed bundles. (B) Epithelioid cells with vesicular nuclei and striking nucleoli. (D) Intra- and extracellular eosinophilic hyaline droplets or globules (A: H&E ×200; B: H&E ×400; C: H&E ×200; D: H&E ×400).
Figure 3
Figure 3
Immunostaining: A. FLi-1 (×200); B. CD31 (×200); C. CK (×200); D. CK18 (×200).
See this image and copyright information in PMC

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