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Comparative Study
. 1989 Jun 24;1(8652):1439-41.
doi: 10.1016/s0140-6736(89)90136-0.

Side-effects of ivermectin in treatment of onchocerciasis

A Rothova  1 , A van der Lelij, J S Stilma, W R Wilson, R F Barbe
Affiliations
Comparative Study

Side-effects of ivermectin in treatment of onchocerciasis

A Rothova et al. Lancet. .

Abstract

In a prospective study to determine the tolerance for and safety of ivermectin therapy for onchocerciasis in a hyperendemic area in Sierra Leone, 28 (32%) of 87 patients had adverse reactions that required treatment with acetylsalicylic acid and antihistamines, but none of the observed adverse reactions were considered life-threatening. A significant relation was found between the frequency and severity of side-effects and the degree of parasite infestation, as quantified by the skin-snip counts. Free administration of ivermectin to severely infected onchocerciasis patients is not recommended without some form of medical supervision.

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