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. 2014 Dec 19:11:63-8.
eCollection 2015 Jan-Apr.

Glomus tumor of the thenar eminence in neurofibromatosis type 1: case report and literature review

Gabriele Scaravilli  1 , Roberto Rossi  1 , Stefano Artiaco  2 , Giovanni Merolla  3
Affiliations

Glomus tumor of the thenar eminence in neurofibromatosis type 1: case report and literature review

Gabriele Scaravilli et al. Transl Med UniSa. .

Abstract

Neurofibromatosis type 1 (NF1) is a disease characterized by increased tumorigenesis susceptibility, caused by mutations of the oncosuppressor gene NF1. The glomus tumor (GT) is a rare, very painful mesenchymal neoplasm, arising from the glomus body. In recent years, it has been highlighted the association between NF1 and GT. We report a case of a man aged 65 years, suffering from NF1, with intense pain at the thenar eminence of the right hand, successfully treated with the excision of the mass.

Keywords: Biallelic Inactivation; Finger; Glomic Tumor; Neurofibromatosis; Pain.

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Figures

Figure 1:
Figure 1:
Eminence thenar of the right hand with the areas where the neoformation was found (black arrows) and the Love test was positive.
Figure 2:
Figure 2:
Typical neurofibromas along the trunk and back of the patient
Figure 3:
Figure 3:
Thermography show the hyperthermic area in the thenar eminence of the right hand where the glomus tumor was located (red arrow).
Figure 4:
Figure 4:
Intraoperative findings. The glomus tumor was excised through a volar approach and was found to to be very shallow. The window on the left top shows the well capsulated neoformation as it appeared at the end of the procedure.
Figure 5:
Figure 5:
Histological findings: blood vessels surrounded by a proliferation of small round cells with dark nuclei in a myxoid stroma.
See this image and copyright information in PMC

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