HSV cheats the executioner

Karen L Mossman¹, Sandra K Weller²

Affiliations

¹ Departments of Biochemistry and Biomedical Sciences and Pathology and Molecular Medicine, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
² Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: weller@uchc.edu.

PMID: 25674981
DOI: 10.1016/j.chom.2015.01.013

Free article

Comment

HSV cheats the executioner

Karen L Mossman et al. Cell Host Microbe. 2015.

Free article

. 2015 Feb 11;17(2):148-51.

doi: 10.1016/j.chom.2015.01.013.

Authors

Karen L Mossman¹, Sandra K Weller²

Affiliations

¹ Departments of Biochemistry and Biomedical Sciences and Pathology and Molecular Medicine, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.
² Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: weller@uchc.edu.

PMID: 25674981
DOI: 10.1016/j.chom.2015.01.013

Abstract

In this issue of Cell Host & Microbe, Huang et al. (2015) and Guo et al. (2015), along with recent work by Wang et al. (2014), reveal that HSV ribonucleotide reductase has opposing activities in either inducing or preventing necroptosis, depending on the host species. This evolutionary twist underscores the importance of selective pressure in virus-host relationships.

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Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense.
Wang X, Li Y, Liu S, Yu X, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S. Wang X, et al. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15438-43. doi: 10.1073/pnas.1412767111. Epub 2014 Oct 14. Proc Natl Acad Sci U S A. 2014. PMID: 25316792 Free PMC article.
RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.
Huang Z, Wu SQ, Liang Y, Zhou X, Chen W, Li L, Wu J, Zhuang Q, Chen C, Li J, Zhong CQ, Xia W, Zhou R, Zheng C, Han J. Huang Z, et al. Cell Host Microbe. 2015 Feb 11;17(2):229-42. doi: 10.1016/j.chom.2015.01.002. Cell Host Microbe. 2015. PMID: 25674982
Herpes simplex virus suppresses necroptosis in human cells.
Guo H, Omoto S, Harris PA, Finger JN, Bertin J, Gough PJ, Kaiser WJ, Mocarski ES. Guo H, et al. Cell Host Microbe. 2015 Feb 11;17(2):243-51. doi: 10.1016/j.chom.2015.01.003. Cell Host Microbe. 2015. PMID: 25674983 Free PMC article.

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HSV cheats the executioner

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HSV cheats the executioner

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