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. 2015 Mar 17;112(6):1017-26.
doi: 10.1038/bjc.2015.53.

Childhood acute lymphoblastic leukaemia and indicators of early immune stimulation: the Estelle study (SFCE)

R Ajrouche  1 , J Rudant  2 , L Orsi  3 , A Petit  4 , A Baruchel  5 , A Lambilliotte  6 , M Gambart  7 , G Michel  8 , Y Bertrand  9 , S Ducassou  10 , V Gandemer  11 , C Paillard  12 , L Saumet  13 , N Blin  14 , D Hémon  3 , J Clavel  2
Affiliations

Childhood acute lymphoblastic leukaemia and indicators of early immune stimulation: the Estelle study (SFCE)

R Ajrouche et al. Br J Cancer. .

Abstract

Background: Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure to infectious agents, normal delivery, and exposure to animals in early life) have been suggested to decrease the risk of childhood acute lymphoblastic leukaemia (ALL).

Methods: The national registry-based case-control study, ESTELLE, was carried out in France in 2010-2011. Population controls were frequency matched with cases on age and gender. The participation rates were 93% for cases and 86% for controls. Data were obtained from structured telephone questionnaires administered to mothers. Odds ratios (OR) were estimated using unconditional regression models adjusted for age, gender, and potential confounders.

Results: In all, 617 ALL and 1225 controls aged ⩾1 year were included. Inverse associations between ALL and early common infections (OR=0.8, 95% confidence interval (CI): 0.6, 1.0), non-first born (⩾3 vs 1; OR=0.7, 95% CI: 0.5, 1.0), attendance of a day-care centre before age 1 year (OR=0.7, 95% CI: 0.5, 1.0), breastfeeding (OR=0.8, 95% CI: 0.7, 1.0), and regular contact with pets (OR=0.8, 95% CI: 0.7, 1.0) in infancy were observed.

Conclusions: The results support the hypothesis that conditions promoting the maturation of the immune system in infancy have a protective role with respect to ALL.

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References

    1. Ajrouche R, Rudant J, Orsi L, Petit A, Baruchel A, Nelken B, Pasquet M, Michel G, Bergeron C, Ducassou S, Gandemer V, Lutz P, Saumet L, Rialland X, Hemon D, Clavel J. Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study. Cancer Causes Control. 2014;25 (10:1283–1293. - PubMed
    1. Altieri A, Castro F, Bermejo JL, Hemminki K. Number of siblings and the risk of lymphoma, leukemia, and myeloma by histopathology. Cancer Epidemiol Biomarkers Prev. 2006;15 (7:1281–1286. - PubMed
    1. Blondel B, Lelong N, Kermarrec M, Goffinet F. Trends in perinatal health in France from 1995 to 2010. Results from the French National Perinatal Surveys. J Gynecol Obstet Biol Reprod. 2012;41 (4:e1–e15. - PubMed
    1. Bross ID, Gibson R. Cats and childhood leukemia. J Med. 1970;1 (3:180–187. - PubMed
    1. Buckley JD, Buckley CM, Ruccione K, Sather HN, Waskerwitz MJ, Woods WG, Robison LL. Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group. Leukemia. 1994;8 (5:856–864. - PubMed

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