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Case Reports
. 2015 Mar;34(2):208-12.
doi: 10.1097/PGP.0000000000000132.

A rare case of HPV-negative cervical squamous cell carcinoma

Shauna Casey  1 , Ian Harley, Jackie Jamison, Anco Molijn, Henk van den Munckhof, W Glenn McCluggage
Affiliations
Case Reports

A rare case of HPV-negative cervical squamous cell carcinoma

Shauna Casey et al. Int J Gynecol Pathol. 2015 Mar.

Abstract

It is generally assumed that virtually all cervical squamous cell carcinomas are associated with persistent infection by high-risk human papillomavirus (HPV), although it is well known that unusual variants of cervical adenocarcinoma are mostly HPV negative. We report a case of a well-differentiated cervical squamous cell carcinoma in a 54-yr-old woman, the morphologic features of which suggested a non-HPV-related neoplasm. The tumor was p16 negative. HPV was also negative by 2 methods, including the highly sensitive SPF-10 system. Further study of additional cases is needed to establish the etiological and pathogenetic factors that underlie very rare non-HPV-related cervical squamous cell carcinoma.

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