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. 1989 Jun;26(2):131-8.
doi: 10.1016/0006-3223(89)90016-4.

Effect of neuroleptic withdrawal on plasma prolactin: a possible marker of receptor adaptation

B Kirkpatrick  1 , R W Buchanan, K Maeda, W T Carpenter Jr, D Jauch, C A Tamminga
Affiliations

Effect of neuroleptic withdrawal on plasma prolactin: a possible marker of receptor adaptation

B Kirkpatrick et al. Biol Psychiatry. 1989 Jun.

Abstract

Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.

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