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Editorial
. 2015 Feb 13;116(4):563-5.
doi: 10.1161/CIRCRESAHA.115.305820.

Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation

Pearl Quijada  1 , Mark A Sussman  2
Affiliations
Editorial

Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation

Pearl Quijada et al. Circ Res. .
No abstract available

Keywords: Editorials; bone marrow cells; cell fusion; cell transdifferentiation; parabiosis.

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Conflict of interest statement

Disclosures: MA Sussman is a founder and co-owner of CardioCreate Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Figures

Figure 1
Figure 1
A schematic summary of the studies performed by Wu et al. to identify circulating cells acquiring cardiomyogenic fate in vivo. Briefly, surgical parabiosis was performed to establish cross-circulation for one-month followed by permanent artery ligation in one of the mouse models. The pair was maintained for 2 weeks before analysis. If tamoxifen was added, the study was extended for an additional 2 weeks. Circulating cells may have heterogeneous cell populations that allow for the derivation of cardiomyocytes, endothelial and smooth muscle, cardiomyocytes through fusion and/or maintenance of hematopoietic blood cells (presented from the lowest to highest frequency) and all of these processes could be impacted by aging of the organism.
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