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Editorial
. 2015 Feb 13;116(4):563-5.
doi: 10.1161/CIRCRESAHA.115.305820.

Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation

Pearl Quijada  1 , Mark A Sussman  2
Affiliations
Editorial

Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation

Pearl Quijada et al. Circ Res. .
No abstract available

Keywords: Editorials; bone marrow cells; cell fusion; cell transdifferentiation; parabiosis.

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Conflict of interest statement

Disclosures: MA Sussman is a founder and co-owner of CardioCreate Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Figures

Figure 1
Figure 1
A schematic summary of the studies performed by Wu et al. to identify circulating cells acquiring cardiomyogenic fate in vivo. Briefly, surgical parabiosis was performed to establish cross-circulation for one-month followed by permanent artery ligation in one of the mouse models. The pair was maintained for 2 weeks before analysis. If tamoxifen was added, the study was extended for an additional 2 weeks. Circulating cells may have heterogeneous cell populations that allow for the derivation of cardiomyocytes, endothelial and smooth muscle, cardiomyocytes through fusion and/or maintenance of hematopoietic blood cells (presented from the lowest to highest frequency) and all of these processes could be impacted by aging of the organism.
See this image and copyright information in PMC

Comment on

References

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