Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec 6;16(6):501.
doi: 10.1186/s13075-014-0501-5.

Anti-tumor necrosis factor patent expiration and the risks of biocopies in clinical practice

Morton Scheinberg, Gilberto Castañeda-Hernández
Review

Anti-tumor necrosis factor patent expiration and the risks of biocopies in clinical practice

Morton Scheinberg et al. Arthritis Res Ther. .

Abstract

Biosimilars that were not compared in clinical trials with the compound innovator are not true biosimilars (biocopies) and are associated with risks that the clinical rheumatologist should be aware of before generalized use. This article comments on various aspects surrounding the use of such biocopies in clinical rheumatology.

PubMed Disclaimer

References

    1. Kuek A, Hazleman BL, Ostör AJ. Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution. Postgrad Med J. 2007;83:251–260. doi: 10.1136/pgmj.2006.052688. - DOI - PMC - PubMed
    1. De Piano LP, Golmia RP, Scheinberg MA. Decreased need of large joint replacement in patients with rheumatoid arthritis in a specialized Brazilian center. Clin Rheumatol. 2011;30:549–550. doi: 10.1007/s10067-010-1629-6. - DOI - PubMed
    1. Thalayasingam N, Isaacs JD. Anti-TNF therapy. Best Pract Res Clin Rheumatol. 2011;25:549–567. doi: 10.1016/j.berh.2011.10.004. - DOI - PubMed
    1. Mota LM, Cruz BA, Brenol CV, Pereira IA, Rezende-Fronza LS, Bertolo MB, Freitas MV, Silva NA, Louzada-Junior P, Giorgi RD, Lima RA, Bernardo WM, Pinheiro Gda R, Sociedade Brasileira de Reumatologia Guidelines for the drug treatment of rheumatoid arthritis. Rev Bras Reumatol. 2013;53:158–183. doi: 10.1590/S0482-50042013000200004. - DOI - PubMed
    1. Mikhail A, Farouk M. Epoetin biosimilars in Europe: five years on. Adv Ther. 2013;30:28–40. doi: 10.1007/s12325-012-0072-2. - DOI - PubMed

MeSH terms

LinkOut - more resources