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Review
. 2015 Mar;42(1):155-65, ix.
doi: 10.1016/j.clp.2014.10.011. Epub 2014 Nov 21.

Chorioamnionitis: implications for the neonate

Jessica E Ericson  1 , Matthew M Laughon  2
Affiliations
Review

Chorioamnionitis: implications for the neonate

Jessica E Ericson et al. Clin Perinatol. 2015 Mar.

Abstract

Chorioamnionitis (CA) is characterized by inflammation of the fetal membranes. The incidence increases with decreasing gestational age at birth. When suspected on clinical criteria, pathologic assessment of the placenta should be performed. Although the mechanisms are not entirely clear, CA predisposes to premature birth, neonatal sepsis, and intraventricular hemorrhage. Its role in respiratory distress syndrome, bronchopulmonary dysplasia, and neurodevelopmental impairment is mixed. Prevention and treatment are ill-defined; antibiotics for preterm premature rupture of membranes reduce the incidence and increase the length of time to delivery. Antibiotics are recommended for infants exposed to CA while laboratory studies are being performed.

Keywords: Fetal inflammatory response; Mycoplasma; Neonatal sepsis.

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References

    1. Hecht JL, Allred EN, Kliman HJ, et al. Histological characteristics of singleton placentas delivered before the 28th week of gestation. Pathology. 2008 Jun;40(4):372–376. - PMC - PubMed
    1. Hillier SL, Martius J, Krohn M, Kiviat N, Holmes KK, Eschenbach DA. A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. The New England journal of medicine. 1988 Oct 13;319(15):972–978. - PubMed
    1. Hecht JL, Fichorova RN, Tang VF, et al. Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns. Pediatric research. 2011 Jan;69(1):68–73. - PMC - PubMed
    1. Plakkal N, Soraisham AS, Trevenen C, Freiheit EA, Sauve R. Histological chorioamnionitis and bronchopulmonary dysplasia: a retrospective cohort study. Journal of perinatology : official journal of the California Perinatal Association. 2013 Jun;33(6):441–445. - PubMed
    1. Liu Z, Tang Z, Li J, Yang Y. Effects of placental inflammation on neonatal outcome in preterm infants. Pediatr Neonatol. 2014 Feb;55(1):35–40. - PubMed

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