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Observational Study
. 2015 Apr;21(2):210-8.
doi: 10.1007/s13365-015-0327-1. Epub 2015 Feb 13.

Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

Anthony J Lee  1 , Ronald J Bosch, Scott R Evans, Kunling Wu, Taylor Harrison, Philip Grant, David B Clifford
Affiliations
Observational Study

Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

Anthony J Lee et al. J Neurovirol. 2015 Apr.

Abstract

The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95% CI) of PN and SPN were 31% (23, 40%) and 5% (2, 11%) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

Trial registration: ClinicalTrials.gov NCT00001137.

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Conflict of interest statement

Conflict of Interest

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Neuropathy over time
Figure 2
Figure 2
Pre-ART neuropathy by pre-ART CD4
None
None
See this image and copyright information in PMC

References

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