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. 1989 Jul 15;2(8655):124-7.
doi: 10.1016/s0140-6736(89)90182-7.

Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine

P S Foster  1 , E Gesini, C Claudianos, K C Hopkinson, M A Denborough
Affiliations

Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine

P S Foster et al. Lancet. .

Abstract

The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.

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