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. 2015 Mar 14;51(21):4458-61.
doi: 10.1039/c4cc10164b.

Methylene blue phosphoramidite for DNA labelling

Gabriel De Crozals  1 , Carole Farre, Monique Sigaud, Philippe Fortgang, Corinne Sanglar, Carole Chaix
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Methylene blue phosphoramidite for DNA labelling

Gabriel De Crozals et al. Chem Commun (Camb). .

Abstract

We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochemical and optical properties of the resulting MB modified oligonucleotides were confirmed. This new molecule is an important breakthrough in the design of new probes labelled with MB.

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