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Review
. 2015 Mar;240(3):305-14.
doi: 10.1177/1535370214561953. Epub 2015 Feb 13.

Alteration of WWOX in human cancer: a clinical view

Izabela Baryła  1 , Ewa Styczeń-Binkowska  1 , Andrzej K Bednarek  2
Affiliations
Review

Alteration of WWOX in human cancer: a clinical view

Izabela Baryła et al. Exp Biol Med (Maywood). 2015 Mar.

Abstract

WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3-24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.

Keywords: WWOX; cancer; tumor suppressor gene.

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