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. 2015 Sep;11(9):1007-14.
doi: 10.1016/j.jalz.2014.11.009. Epub 2015 Feb 11.

MIND diet associated with reduced incidence of Alzheimer's disease

Martha Clare Morris  1 , Christy C Tangney  2 , Yamin Wang  3 , Frank M Sacks  4 , David A Bennett  5 , Neelum T Aggarwal  5
Affiliations

MIND diet associated with reduced incidence of Alzheimer's disease

Martha Clare Morris et al. Alzheimers Dement. 2015 Sep.

Abstract

Introduction: In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean-Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these three dietary patterns to incident Alzheimer's disease (AD).

Methods: We investigated the diet-AD relations in a prospective study of 923 participants, ages 58 to 98 years, followed on average 4.5 years. Diet was assessed by a semiquantitative food frequency questionnaire.

Results: In adjusted proportional hazards models, the second (hazards ratio or HR = 0.65, 95% confidence interval or CI 0.44, 0.98) and highest tertiles (HR = 0.47, 95% CI 0.26, 0.76) of MIND diet scores had lower rates of AD versus tertile 1, whereas only the third tertiles of the DASH (HR = 0.61, 95% CI 0.38, 0.97) and Mediterranean (HR = 0.46, 95% CI 0.26, 0.79) diets were associated with lower AD rates.

Discussion: High adherence to all three diets may reduce AD risk. Moderate adherence to the MIND diet may also decrease AD risk.

Keywords: Aging; Alzheimer's disease; Cognition; Epidemiological study; Nutrition; diet.

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Figures

Figure 1a. – 1c
Figure 1a. – 1c
Survivor function for incident AD by tertile of a. the MIND diet, b. the MedDiet , and c. the DASH diet based on Cox proportional hazards models adjusted for age, sex, education, APOE-ε4 (any), participation in cognitively stimulating activities, physical activity and total energy intake
Figure 1a. – 1c
Figure 1a. – 1c
Survivor function for incident AD by tertile of a. the MIND diet, b. the MedDiet , and c. the DASH diet based on Cox proportional hazards models adjusted for age, sex, education, APOE-ε4 (any), participation in cognitively stimulating activities, physical activity and total energy intake
Figure 1a. – 1c
Figure 1a. – 1c
Survivor function for incident AD by tertile of a. the MIND diet, b. the MedDiet , and c. the DASH diet based on Cox proportional hazards models adjusted for age, sex, education, APOE-ε4 (any), participation in cognitively stimulating activities, physical activity and total energy intake
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