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Review
. 2015 Mar;42(1):15-25.
doi: 10.1016/j.ogc.2014.09.005. Epub 2014 Dec 5.

Age-related infertility

Natalie M Crawford  1 , Anne Z Steiner  2
Affiliations
Review

Age-related infertility

Natalie M Crawford et al. Obstet Gynecol Clin North Am. 2015 Mar.

Abstract

Oocyte number and quality decrease with advancing age. Thus, fecundity decreases as age increases, with a more rapid decline after the mid-30s. Patients more than 35 years old should receive prompt evaluation for causes of infertility after no more than 6 months of attempted conception. Patients with abnormal tests of ovarian reserve have a poorer prognosis and may need more expedited and aggressive treatment. Although oocyte donation is the best method to overcome age-related infertility, other treatment options may help women proceed quicker toward pregnancy. Patients at an advanced age should be counseled and evaluated before undergoing infertility treatments.

Keywords: Advanced maternal age; Aging; Donor oocytes; Infertility; Ovarian reserve.

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