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Case Reports
. 2015 May;62(5):909-11.
doi: 10.1002/pbc.25424. Epub 2015 Feb 14.

FN1: a novel fusion partner of ALK in an inflammatory myofibroblastic tumor

Kazutaka Ouchi  1 , Mitsuru Miyachi, Yusuke Tsuma, Kunihiko Tsuchiya, Tomoko Iehara, Eiichi Konishi, Akio Yanagisawa, Hajime Hosoi
Affiliations
Case Reports

FN1: a novel fusion partner of ALK in an inflammatory myofibroblastic tumor

Kazutaka Ouchi et al. Pediatr Blood Cancer. 2015 May.

Abstract

Inflammatory myofibroblastic tumors (IMTs) are rare tumors characterized as low-to-intermediate grade sarcomas. Rearrangements of the anaplastic lymphoma kinase (ALK) gene have been reported in IMT. Here, we describe a novel fusion gene in an IMT tumor specimen. A 12-year-old male was admitted to our hospital with a bladder tumor. We identified the fibronectin 1 gene (FN1) as a fusion partner of ALK using 5'RACE. This novel fusion, FN1-ALK, resulted in ALK overexpression in the IMT. This finding should clarify the causes of IMT and facilitate development of novel therapeutics.

Keywords: ALK gene fusion; FN1; inflammatory myofibroblastic tumor.

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