Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Mar;41(3):194-6.
doi: 10.1111/j.2042-7158.1989.tb06429.x.

The transport of microspheres from the gastro-intestinal tract to inflammatory air pouches in the rat

H O Alpar  1 , W N Field, R Hyde, D A Lewis
Affiliations

The transport of microspheres from the gastro-intestinal tract to inflammatory air pouches in the rat

H O Alpar et al. J Pharm Pharmacol. 1989 Mar.

Abstract

The distribution of latex microspheres (1.1 microns diam) has been investigated in-vivo, as a potential passive targeted system for the treatment of inflammation. Microspheres administered orally were found in the circulation and in inflamed tissues and exudates of inflammatory air pouches in rats. Oral absorption was also found in a rabbit. Particles administered directly into the circulation also penetrated into the air pouch tissues and fluids. The possibility of using microspheres as a passive targeted system for the treatment of inflammation is discussed.

PubMed Disclaimer

LinkOut - more resources