Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Jan-Feb;25(1):54-6.
doi: 10.4103/0971-4065.136883.

Acute interstitial nephritis due to statin and its class effect

R A Annigeri  1 , R M Mani  2
Affiliations
Case Reports

Acute interstitial nephritis due to statin and its class effect

R A Annigeri et al. Indian J Nephrol. 2015 Jan-Feb.

Abstract

Recent reports indicate that statins can cause nephrotoxicity. However, the mechanisms of nephrotoxicity remain unclear. We report a case of acute kidney injury (AKI) in a 54-year-old man following the administration of atorvastatin Renal biopsy showed acute interstitial nephritis. Atorvastatin was withdrawn and he was treated with corticosteroid following which renal function recovered. When he was rechallenged with rosuvastatin 6 months later following an episode of acute myocardial infarction, he developed AKI again indicating class effect of statin for nephrotoxicity.

Keywords: Acute interstitial nephritis; acute kidney injury; statins.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Microscopy of renal biopsy (a: ×10; b: ×40) showing acute interstitial nephritis
Figure 2
Figure 2
Serum creatinine over period after starting atorvastatin 20 mg (solid line) and after rechallenge with another statin, rosuvastatin 10 mg (interrupted line). Black arrow indicates initiation of corticosteroid; white arrow, indicates withdrawal of statin
See this image and copyright information in PMC

References

    1. Mihaylova B, Emberson J, Blackwell L, Keech A, Simes J, et al. Cholesterol Treatment Trialists’ (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials. Lancet. 2012;380:581–90. - PMC - PubMed
    1. Deedwania P, Stone PH, Bairey Merz CN, Cosin-Aguilar J, Koylan N, Luo D, et al. Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: Results of the Study Assessing Goals in the Elderly (SAGE) Circulation. 2007;115:700–7. - PubMed
    1. Law M, Rudnicka AR. Statin safety: Systematic review. Am J Cardiol. 2006;97:52C–60. - PubMed
    1. Mithani S, Kuskowski M, Slinin Y, Ishani A, McFalls E, Adabag S. Dose-dependent effect of statins on the incidence of acute kidney injury after cardiac surgery. Ann Thorac Surg. 2011;91:520–5. - PubMed
    1. Khanal S, Attallah N, Smith DE, Kline-Rogers E, Share D, O’Donnell MJ, et al. Statin therapy reduces contrast-induced nephropathy: An analysis of contemporary percutaneous interventions. Am J Med. 2005;118:843–9. - PubMed

Publication types

LinkOut - more resources