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. 2014 Dec 18;4(3):509-16.
doi: 10.1159/000357775. eCollection 2014 Sep-Dec.

The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline

Sarah Jane Banks  1 , Rema Raman  2 , Feng He  2 , David P Salmon  2 , Steven Ferris  3 , Paul Aisen  2 , Jeffrey Cummings  1
Affiliations

The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline

Sarah Jane Banks et al. Dement Geriatr Cogn Dis Extra. .

Abstract

Background/methods: The Alzheimer's Disease Cooperative Study Prevention Instrument Project is a longitudinal study that recruited 644 cognitively healthy older subjects (aged between 75 and 93 years, 58% women) at baseline and evaluated their cognitive change over 4 years. The study was structured like a clinical trial to anticipate a prevention trial and to determine the performance of novel trial instruments in a longitudinal non-interventional trial framework. Behavioral symptoms were assessed at baseline.

Results: The existence of participant-reported behavioral symptoms at baseline predicted conversion to Clinical Dementia Rating scale score ≥0.5 over the 4-year period.

Conclusions: The results imply that early anxiety and depression may be harbingers of future cognitive decline, and that patients exhibiting such symptoms, even in the absence of co-occurring cognitive symptoms, should be closely followed over time.

Keywords: Aging; Alzheimer's disease; Anxiety; Depression; Mild cognitive impairment.

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Figures

Fig. 1
Fig. 1
Percentage of participants reporting each symptom at baseline, separated by subject and partner.
See this image and copyright information in PMC

References

    1. Hwang TJ, Masterman DL, Ortiz F, Fairbanks LA, Cummings JL. Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Dis Assoc Disord. 2004;18:17–21. - PubMed
    1. Ferris SH, Aisen PS, Cummings J, et al. ADCS Prevention Instrument Project: overview and initial results. Alzheimer Dis Assoc Disord. 2006;20((4 suppl 3)):S109–S123. - PubMed
    1. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412–2414. - PubMed
    1. Sachs-Ericsson N, Joiner T, Plant EA, Blazer DG. The influence of depression on cognitive decline in community-dwelling elderly persons. Am J Geriatr Psychiatry. 2005;13:402–408. - PubMed
    1. van Reekum R, Simard M, Clarke D, Binns MA, Conn D. Late-life depression as a possible predictor of dementia: cross-sectional and short-term follow-up results. Am J Geriatr Psychiatry. 1999;7:151–159. - PubMed