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Review
. 2014 Dec 24;14(12):e22915.
doi: 10.5812/hepatmon.22915. eCollection 2014 Dec.

Prevalence of hepatitis C virus genotypes in Iranian patients: a systematic review and meta-analysis

Mazaher Khodabandehloo  1 , Daem Roshani  2
Affiliations
Review

Prevalence of hepatitis C virus genotypes in Iranian patients: a systematic review and meta-analysis

Mazaher Khodabandehloo et al. Hepat Mon. .

Abstract

Context: Hepatitis C virus (HCV) is a global public health problem and a major etiology of chronic liver disease, which may develop into cirrhosis and hepatocellular carcinoma. Genotypes of HCV indicate the route of acquisition, the clinical outcome, response to treatment, prognosis and control strategies.

Objectives: The aim of this study was to estimate the overall prevalence and trend of HCV genotypes or subtypes in Iran.

Data sources: A literature review was done for papers reporting HCV genotypes in Iranian patients in PubMed, Magiran, IranMedex, Scientific Information Databank, and Google scholar databases.

Study selection: Data were selected according to inclusion and exclusion criteria.

Data extraction: Data were abstracted by two independent authors. Data were analyzed based on random-effects model using the Meta R. Pooled statistical software. Prevalence of HCV genotypes in cities and provinces of Iran with 95% confidence interval (CI) were calculated.

Results: Fifty-three articles published between 1999 and 31 June 2014 including 22952 HCV infected individuals were included in the meta-analysis. Subtype 1a was predominant with a rate of 39% (95% CI: 34-44%); followed by subtype 3a, 32% (95% CI: 26-39%); subtype 1b, 13% (95% CI: 10-15%); genotype 4, 5.18% (95% CI: 3.27-7.5%); and genotype 2, 3.6% (95% CI: 1.6-8.3%). Untypeable HCV had a rate of 0.11% (95% CI: 0.07-0.16%).

Conclusions: The most frequent subtypes of HCV in Iran were 1a, 3a and 1b, respectively. This frequency differed in various provinces of Iran and fluctuated with time. It is important to determine the distribution of HCV genotypes in different geographical areas and its trend with time for epidemiological and patients' management purposes.

Keywords: Genotypes; Hepatitis C virus; Iran; Molecular Epidemiology.

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Figures

Figure 1.
Figure 1.. Flow Chart of Literature Search for Original Articles in English and Persian Reporting HCV Genotypes and Subtypes From Provinces and Cities of Iran
Figure 2.
Figure 2.. Forest Plot Showing Hepatitis C Virus Genotypes and Subtypes 1a, 1b, 2, 3a and 4 Prevalence Estimates in Patients of Iranian Cities and Provinces
Figure 3.
Figure 3.. Forest Plot Showing Hepatitis C Virus Genotypes and Subtypes 1a, 1b, 2, 3a and 4, Prevalence Estimates in Iranian Patients According to Study Period
Figure 4.
Figure 4.. Funnel Plot Detecting Biases in the Identification and Selection of Studies for HCV Genotypes and Subtypes 1a, 1b, 2, 3a, and 4 in Iranian Cities and Provinces
Figure 5.
Figure 5.. Funnel Plot Detecting Biases in the Identification and Selection of Studies for HCV Genotypes and Subtypes 1a, 1b, 2, 3a, and 4 According to Study Periods
See this image and copyright information in PMC

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