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Clinical Trial
. 1989 Jul 22;2(8656):177-81.
doi: 10.1016/s0140-6736(89)90370-x.

Randomised trial of fish oil for prevention of restenosis after coronary angioplasty

G J Reis  1 , T M Boucher, M E Sipperly, D I Silverman, C H McCabe, D S Baim, F M Sacks, W Grossman, R C Pasternak
Affiliations
Free article
Clinical Trial

Randomised trial of fish oil for prevention of restenosis after coronary angioplasty

G J Reis et al. Lancet. .
Free article

Abstract

To examine the potential role of fish oil supplementation in the prevention of restenosis after coronary angioplasty (PTCA), a randomised double-blind trial was conducted in 204 patients. The treatment group received 6 g/day of n-3 fatty acids, beginning 5.4 (SD 3.2) days before PTCA, and continuing for 6 months; the control group received olive oil placebo. Compliance was assessed by pill count and plasma levels of eicosapentaenoic acid (EPA). Restenosis was identified by symptoms and exercise testing and confirmed by angiography. PTCA was successful in 186 patients (93%). The incidence of angiographic restenosis was 34% in the fish oil group and 23% in the control group (relative risk 1.7, 95% CI 0.9-3.4). The lack of benefit of fish oil was not influenced by length of pretreatment, compliance with study medication, or the concentrations of plasma EPA achieved.

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Comment in

  • Fish oil versus olive oil.
    Budiarso IT. Budiarso IT. Lancet. 1990 Nov 24;336(8726):1313-4. doi: 10.1016/0140-6736(90)92993-r. Lancet. 1990. PMID: 1978131 No abstract available.
  • Fish oil and coronary angioplasty.
    [No authors listed] [No authors listed] Lancet. 1989 Aug 19;2(8660):443. Lancet. 1989. PMID: 2569619 Clinical Trial. No abstract available.

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