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. 1989 Jul 22;2(8656):205-6.
doi: 10.1016/s0140-6736(89)90382-6.

Sputum induction for diagnosis of Pneumocystis carinii pneumonia

T R Leigh  1 , P Parsons, C Hume, O A Husain, B Gazzard, J V Collins
Affiliations

Sputum induction for diagnosis of Pneumocystis carinii pneumonia

T R Leigh et al. Lancet. .

Abstract

51 patients infected with the human immunodeficiency virus (HIV) and with suspected Pneumocystis carinii pneumonia underwent sputum induction. Sputum specimens from 18 patients were positive for P carinii and patients were treated appropriately 25 of the 33 patients with negative specimens underwent bronchoscopy and bronchoalveolar lavage within 4 days of sputum induction, only 1 of whom had evidence of Pneumocystis infection. For diagnosis of Pneumocystis carinii pneumonia, sputum induction according to a strict protocol had a sensitivity of 94.7% and a negative predictive value of 96%, compared with bronchoalveolar lavage.

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