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. 2015:2015:467243.
doi: 10.1155/2015/467243. Epub 2015 Jan 19.

A rare combination of ovarian and uterine leiomyomas with goblet cell carcinoid of the appendix

Abdulrahman F Al-Shaikh  1 , Abdulla Darwish  2 , Veena Nagaraj  2 , Abeer Alsada  3
Affiliations

A rare combination of ovarian and uterine leiomyomas with goblet cell carcinoid of the appendix

Abdulrahman F Al-Shaikh et al. Case Rep Surg. 2015.

Abstract

We present a case of the rare combination of unilateral ovarian leiomyoma, uterine leiomyoma, and goblet cell carcinoid tumor of the appendix in a premenopausal woman who presented with right iliac pain. Immunohistochemistry study for desmin (muscle marker) and chromogranin and synaptophysin (neuroendocrine markers) confirmed immunophenotyping origin. Interestingly, both tumors showed positive reaction for estrogen receptor. To our knowledge, such a combination has not been reported previously in the literature. In this paper, the pathogenesis and differential diagnosis of both types of tumors are discussed.

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Figures

Figure 1
Figure 1
Laparoscopic intraoperative view of the right ovary, right tube, and part of the uterus. The right ovary is noted to be enlarged with a 5 × 3 cm hard mass separated from the uterus not adherent to or infiltrating the surroundings.
Figure 2
Figure 2
Low power microscopic view showing a normal ovarian tissue in the left side with a well-defined leiomyoma in the right side of the picture (H&E).
Figure 3
Figure 3
High power view of the ovarian leiomyoma composed of interlacing spindle cells with characteristic cigar-shaped nuclei (H&E).
Figure 4
Figure 4
Low microscopic view shows diffuse strong positivity of the ovarian leiomyoma cells for desmin marker confirming smooth cell origin (immunohistochemistry stain).
Figure 5
Figure 5
Low power microscopic view of the goblet cell carcinoid involving the entire wall to serosal level of the distal part of the appendix (H&E stained).
Figure 6
Figure 6
Microscopic view of the goblet cell carcinoid showing strong positive reaction of the tumor for the chromogranin marker (immunohistochemistry stain).
See this image and copyright information in PMC

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