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Observational Study
. 2015:2015:787451.
doi: 10.1155/2015/787451. Epub 2015 Jan 20.

The "gender factor" in wearing-off among patients with Parkinson's disease: a post hoc analysis of DEEP study

Delia Colombo  1 , Giovanni Abbruzzese  2 , Angelo Antonini  3 , Paolo Barone  4 , Gilberto Bellia  1 , Flavia Franconi  5 , Lucia Simoni  6 , Mahmood Attar  1 , Emanuela Zagni  1 , Shalom Haggiag  7 , Fabrizio Stocchi  8
Affiliations
Observational Study

The "gender factor" in wearing-off among patients with Parkinson's disease: a post hoc analysis of DEEP study

Delia Colombo et al. ScientificWorldJournal. 2015.

Abstract

Background: The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson's disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena.

Methods: Patients on dopaminergic treatment for ≥ 1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥ 2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO.

Results: Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists' judgment (61.9% versus 53.8%, P = 0.045) and the WOQ-19 analysis (72.5% versus 64.0%, P = 0.034). In patients with WO (WOQ-19), women experienced ≥ 1 motor symptom in 72.5% versus 64.0% in men and ≥ 1 nonmotor symptom in 44.5% versus 36.7%, in men.

Conclusions: Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.

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Figures

Figure 1
Figure 1
Rates of WO diagnosis according to WOQ-19 stratified by disease duration: women versus men.
Figure 2
Figure 2
Rates of motor and nonmotor WO symptoms: women versus men.
See this image and copyright information in PMC

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