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Comparative Study
. 2015 Jul;135(7):1921-1924.
doi: 10.1038/jid.2015.50. Epub 2015 Feb 16.

Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain

Jonathan P Andrews  1 , Jaana Marttala  1 , Edward Macarak  2 , Joel Rosenbloom  2 , Jouni Uitto  3
Affiliations
Comparative Study

Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain

Jonathan P Andrews et al. J Invest Dermatol. 2015 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Expression of FN-EDA in keloid tissues (a). Note 70-fold increase in mRNA levels in keloid tissue versus control (n = 5 for both groups; mean ± SE; p = 0.005851). Western blot results for tissue protein isolates from three keloid samples and three control samples (b). A total of 20μg protein was loaded into each well; presence of fibronectin1EDA (220 kD) is demonstrated in keloid extracts versus near total absence in controls. Positive control (β-actin) is present in each protein isolate (42 kD). Immunofluorescence of frozen sections of keloid (1c, left and 1d; scale bar = 30 μm) and control skin (1c, right). Note the heavy decoration of the surfaces of the type III collagen fibers (shown in red) with FN-EDA antibody (shown in green), in keloids in contrast to complete absence of FN-EDA in control skin (1c, right).
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