Chronic neuroleptic-induced mouth movements in the rat: suppression by CCK and selective dopamine D1 and D2 receptor antagonists
- PMID: 2568657
- DOI: 10.1007/BF00451690
Chronic neuroleptic-induced mouth movements in the rat: suppression by CCK and selective dopamine D1 and D2 receptor antagonists
Abstract
Fluphenazine decanoate (25 mg/kg IM every 3 weeks x 6) resulted in spontaneous vacuous chewing mouth movements and jaw tremor in male Sprague-Dawley rats. These movements could be suppressed by the selective D1 or D2 dopamine antagonists SCH 23390 (0.5 mg/kg) and raclopride (0.5 mg/kg), respectively, and by CCK-8S (50 micrograms/kg). Fluphenazine-induced mouth movements were unaffected by the selective CCK antagonist MK-329, and by a dose of physostigmine (50 micrograms/kg) sufficient to stimulate mouth movements in placebo treated rats. Scopolamine (0.1 mg/kg) suppressed spontaneous mouth movements in placebo-treated rats, but the effect on fluphenazine-induced mouth movements was not significant. A higher dose of scopolamine (0.5 mg/kg) did suppress the neuroleptic-induced mouth movements, but also induced hyperactivity, characterized by increased sniffing and grooming. These findings indicate that mouth movements resulting from the chronic administration of neuroleptics to the rat may serve as a useful pharmacological model of tardive dyskinesia in the human, and suggest that a relative increase of D1 activity as well as impaired CCK function may contribute to the pathogenesis of this disorder.
Similar articles
-
Persistent vacuous chewing in rats following neuroleptic treatment: relationship to dopaminergic and cholinergic function.Psychopharmacology (Berl). 1993;113(2):157-66. doi: 10.1007/BF02245692. Psychopharmacology (Berl). 1993. PMID: 7855176
-
Behavioural evidence for cholecystokinin-dopamine D1 receptor interactions in the rat.Eur J Pharmacol. 1996 Feb 29;298(1):7-15. doi: 10.1016/0014-2999(95)00767-9. Eur J Pharmacol. 1996. PMID: 8867913
-
Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats.Behav Neural Biol. 1988 Sep;50(2):240-5. doi: 10.1016/s0163-1047(88)90911-9. Behav Neural Biol. 1988. PMID: 2906537
-
SCH 23390-induced hypophagia is blocked by the selective CCK-A receptor antagonist devazepide, but not by the CCK-B/gastrin receptor antagonist L-365,260.Brain Res Bull. 1990 Apr;24(4):631-3. doi: 10.1016/0361-9230(90)90170-5. Brain Res Bull. 1990. PMID: 2141538
-
The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment.Eur J Pharmacol. 1990 Sep 4;186(1):49-59. doi: 10.1016/0014-2999(90)94059-7. Eur J Pharmacol. 1990. PMID: 1980891
Cited by
-
Effects of ceruletide on the dopamine receptor-adenylate cyclase system in striatum and frontal cortex of rats chronically treated with haloperidol.Psychopharmacology (Berl). 1993;110(4):383-9. doi: 10.1007/BF02244642. Psychopharmacology (Berl). 1993. PMID: 7870906
-
Persistent catalepsy associated with severe dyskinesias in rats treated with chronic injections of haloperidol decanoate.Psychopharmacology (Berl). 1995 Mar;118(2):142-9. doi: 10.1007/BF02245832. Psychopharmacology (Berl). 1995. PMID: 7617800
-
Drugs acting at D-1 and D-2 dopamine receptors induce identical purposeless chewing in rats which can be differentiated by cholinergic manipulation.Psychopharmacology (Berl). 1991;103(4):503-12. doi: 10.1007/BF02244250. Psychopharmacology (Berl). 1991. PMID: 1676528
-
Vacuous jaw movements induced by sub-chronic administration of haloperidol: interactions with scopolamine.Psychopharmacology (Berl). 1993;111(1):99-105. doi: 10.1007/BF02257414. Psychopharmacology (Berl). 1993. PMID: 7870941
-
Persistent vacuous chewing in rats following neuroleptic treatment: relationship to dopaminergic and cholinergic function.Psychopharmacology (Berl). 1993;113(2):157-66. doi: 10.1007/BF02245692. Psychopharmacology (Berl). 1993. PMID: 7855176
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous