Review
doi: 10.1016/0278-5846(89)90125-5.
Brain monoamine oxidase (MAO) B: a unique neurotoxin and neurotransmitter producing enzyme
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- PMID: 2568664
- DOI: 10.1016/0278-5846(89)90125-5
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Review
Brain monoamine oxidase (MAO) B: a unique neurotoxin and neurotransmitter producing enzyme
Prog Neuropsychopharmacol Biol Psychiatry.
1989.
Abstract
The notion that monoamine oxidase (MAO) functions solely to inactivate neurotransmitter and other biogenic amines needs to be re-evaluated. It is now apparent that MAO-B is capable of oxidizing inert non-polar amines such as MPTP (N-methyl-4-phenyl-1,2,3,6, tetrahydropyridine) and milacemide (2-n-pentylaminoacetamide) into neuroactive substances giving rise to Parkinson inducing dopaminergic neurotoxin, MPP+ and inhibitory amino acid neurotransmitter, glycine respectively. These findings accord new prospectives for neuropsychotherapy with selective MAO-B inhibitors and substrates.
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