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. 2015 May;122(5):934-8.
doi: 10.1016/j.ophtha.2015.01.003. Epub 2015 Feb 14.

Sarcoidosis in the national veteran population: association of ocular inflammation and mortality

Andrea D Birnbaum  1 , Dustin D French  2 , Mehdi Mirsaeidi  3 , Sarah Wehrli  4
Affiliations

Sarcoidosis in the national veteran population: association of ocular inflammation and mortality

Andrea D Birnbaum et al. Ophthalmology. 2015 May.

Abstract

Purpose: To describe the distribution of ocular sarcoidosis in the veteran population and to determine the association between ocular disease and all-cause mortality.

Design: Retrospective review.

Methods: The Veterans Health Administration National Patient Care Database information on medical diagnoses, date of diagnosis, age, race, gender, and Veterans Administration medical center station number for site-specific calculations for fiscal years 2010 through 2012 was collected. Mortality data were obtained from the Beneficiary Identification Records Locator Subsystem. The patient cohort was identified with a primary diagnosis of sarcoidosis using International Classification of Disease, ninth edition, code of 135 in outpatient treatment files for the study period. The sarcoidosis patients were divided into those with uveitis or orbital inflammation (defined as ocular inflammation for this study) and those without uveitis or orbital inflammation. Survival analysis was performed using the Cox proportional hazard method.

Main outcome measure: Association between ocular inflammation and 1-year mortality.

Results: Of 15 130 subjects with sarcoidosis, 3364 (22.2%) were evaluated in an eye clinic within a Veterans Administration Medical Center. Most patients were diagnosed with anterior uveitis (n = 1013; 80.7% of ocular inflammation), and the least common diagnosis was orbital granuloma (n = 28; 2.2% of ocular inflammation). Male gender was protective to the development of uveitis (estimate, 0.76; 95% confidence interval, 0.65-0.88; P = 0.0005). The overall 1-year all-cause mortality for all patients with a diagnosis of sarcoidosis was 2.0%. Ocular inflammation was associated with a decrease in 1-year all-cause mortality (simple model: hazard ratio, 0.36; P = 0.0015; complex model: hazard ratio, 0.35; P = 0.013).

Conclusions: Veterans with ocular inflammation had significantly lower 1-year all-cause mortality than those without documented ocular inflammation. The reason for this finding remains to be established.

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References

    1. Baughman RP, Teirstein AS, Judson MA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1885–9. - PubMed
    1. Gilman MJ, Wang KP. Transbronchial lung biopsy in sarcoidosis. An approach to determine the optimal number of biopsies. Am Rev Respir Dis. 1980;122:721–4. - PubMed
    1. Judson MA, Boan AD, Lackland DT. The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States. Sarcoidosis Vasc Diffuse Lung Dis. 2012;29:119–27. - PubMed
    1. Herbort CP, Rao NA, Mochizuki M members of Scientific Committee of First International Workshop on Ocular S. International criteria for the diagnosis of ocular sarcoidosis: results of the first International Workshop On Ocular Sarcoidosis (IWOS) Ocul Immunol Inflamm. 2009;17:160–9. - PubMed
    1. Takase H, Mochizuki M. The role of imaging in the diagnosis and management of ocular sarcoidosis. Int Ophthalmol Clin. 2012;52:113–20. - PubMed

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