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Comment
. 2015 Feb 13:4:e06453.
doi: 10.7554/eLife.06453.

Digging for biosynthetic dark matter

Jia Jia Zhang  1 , Bradley S Moore  2
Affiliations
Comment

Digging for biosynthetic dark matter

Jia Jia Zhang et al. Elife. .

Abstract

An analysis of bacterial communities in soil samples from around the world reveals unexplored diversity in biosynthetic enzymes.

Keywords: biogeography; biosynthesis; evolutionary biology; genomics; infectious disease; metagenomics; microbiology; natural products; none.

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Conflict of interest statement

Competing interests:The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. Unearthing biosynthetic diversity in soil-dwelling bacteria.
Charlop-Powers et al. undertook a large-scale PCR and sequencing effort to identify and compare biosynthetic genes from bacterial communities in soil samples collected from around the world.
See this image and copyright information in PMC

Comment on

References

    1. Charlop-Powers Z, Owen J, Reddy B, Ternei M, Guimaraes D, de Frias U, Pupo M, Seepe P, Feng Z, Brady S. Global biogeographic sampling of bacterial secondary metabolism. eLife. 2015;4:e05048. doi: 10.7554/eLife.05048. - DOI - PMC - PubMed
    1. Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, et al. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 2014;158:412–421. doi: 10.1016/j.cell.2014.06.034. - DOI - PMC - PubMed
    1. Goh EB, Yim G, Tsui W, McClure J, Surette MG, Davies J. Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proceedings of the National Academy of Sciences of USA. 2002;99:17025–17030. doi: 10.1073/pnas.252607699. - DOI - PMC - PubMed
    1. Kinkel LL, Schlatter DC, Xiao K, Baines AD. Sympatric inhibition and niche differentiation suggest alternative coevolutionary trajectories among Streptomycetes. ISME Journal. 2014;8:249–256. doi: 10.1038/ismej.2013.175. - DOI - PMC - PubMed
    1. Li JW, Vederas JC. Drug discovery and natural products: end of an era or an endless frontier? Science. 2009;325:161–165. doi: 10.1126/science.1168243. - DOI - PubMed