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. 2015 Oct;47(4):569-74.
doi: 10.4143/crt.2014.085. Epub 2015 Feb 12.

Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009

Sang-Hoon Shin  1 , Kyu-Won Jung  2 , Johyun Ha  2 , Seung Hoon Lee  1 , Young-Joo Won  2 , Heon Yoo  1
Affiliations

Population-based Incidence and Survival for Primary Central Nervous System Lymphoma in Korea, 1999-2009

Sang-Hoon Shin et al. Cancer Res Treat. 2015 Oct.

Abstract

Purpose: Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries.

Materials and methods: Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate the observed survival, we restricted the data to between 1999 and 2007 and followed the cases until December 2010. The overall survival was estimated using the Kaplan-Meier method, and piecewise Poisson regression model.

Results: The ASR for PCNSL between 1999 and 2009 was 0.17 per 100,000, and the annual percent change from 1999 to 2009 was 8.8% (p < 0.001). The ASR of males was higher than that of females, and the older groups (60s or over) showed the largest increase in incidence rates. For all ages, the five-year survival from PCNSL was 29.9% between 1999 and 2007. Survival from PCNSL is known to show strong association with age at diagnosis.

Conclusion: These results are similar to those of previous studies. Our findings may be helpful to clinicians and patients in determining long-term prognoses for PCNSL.

Keywords: Central nervous system; Incidence; Korea; Lymphoma; Neoplasms; Registries; Survival.

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Conflict of interest statement

Conflict of interest relevant to this article was not reported.

Figures

Fig. 1.
Fig. 1.
Incidence rate trends in central nervous system lymphoma, Korea, 1999-2009.
Fig. 2.
Fig. 2.
Trends in age-specific rates of central nervous system lymphoma by period of diagnosis, Korea, 1999-2009.
Fig. 3.
Fig. 3.
Survival curves by age of diagnosis (yr), 1999-2007.
Fig. 4.
Fig. 4.
Survival curves by year of diagnosis, 1999-2007.
Fig. 5.
Fig. 5.
Survival curves by sex, 1999-2000.
See this image and copyright information in PMC

References

    1. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29:252–60. - PubMed
    1. Olson JE, Janney CA, Rao RD, Cerhan JR, Kurtin PJ, Schiff D, et al. The continuing increase in the incidence of primary central nervous system non-Hodgkin lymphoma: a surveillance, epidemiology, and end results analysis. Cancer. 2002;95:1504–10. - PubMed
    1. Schlegel U, Schmidt-Wolf IG, Deckert M. Primary CNS lymphoma: clinical presentation, pathological classification, molecular pathogenesis and treatment. J Neurol Sci. 2000;181:1–12. - PubMed
    1. Eby NL, Grufferman S, Flannelly CM, Schold SC, Jr, Vogel FS, Burger PC. Increasing incidence of primary brain lymphoma in the US. Cancer. 1988;62:2461–5. - PubMed
    1. Jung KW, Yoo H, Kong HJ, Won YJ, Park S, Lee SH. Population-based survival data for brain tumors in Korea. J Neurooncol. 2012;109:301–7. - PubMed

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