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Comment

. 2015 Mar;12(3):125.

doi: 10.1038/nrclinonc.2015.23. Epub 2015 Feb 17.

Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?

PMID: 25687907
DOI: 10.1038/nrclinonc.2015.23

Comment

Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?

David Killock. Nat Rev Clin Oncol. 2015 Mar.

. 2015 Mar;12(3):125.

doi: 10.1038/nrclinonc.2015.23. Epub 2015 Feb 17.

Author

PMID: 25687907
DOI: 10.1038/nrclinonc.2015.23

No abstract available

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Comment on

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.
Mateos-Gomez PA, Gong F, Nair N, Miller KM, Lazzerini-Denchi E, Sfeir A. Mateos-Gomez PA, et al. Nature. 2015 Feb 12;518(7538):254-7. doi: 10.1038/nature14157. Epub 2015 Feb 2. Nature. 2015. PMID: 25642960 Free PMC article.
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Ceccaldi R, et al. Nature. 2015 Feb 12;518(7538):258-62. doi: 10.1038/nature14184. Epub 2015 Feb 2. Nature. 2015. PMID: 25642963 Free PMC article.

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References

1. Nature. 2015 Feb 12;518(7538):254-7 - PubMed
1. Nature. 2015 Feb 12;518(7538):258-62 - PubMed

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