Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?
- PMID: 25687907
- DOI: 10.1038/nrclinonc.2015.23
Targeted therapies: DNA polymerase θ-a new target for synthetic lethality?
Comment on
-
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.Nature. 2015 Feb 12;518(7538):254-7. doi: 10.1038/nature14157. Epub 2015 Feb 2. Nature. 2015. PMID: 25642960 Free PMC article.
-
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.Nature. 2015 Feb 12;518(7538):258-62. doi: 10.1038/nature14184. Epub 2015 Feb 2. Nature. 2015. PMID: 25642963 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
