Hyperglycemia diverts dividing stem cells to pathological adipogenesis
- PMID: 25689074
- PMCID: PMC4339424
- DOI: 10.1186/scrt518
Hyperglycemia diverts dividing stem cells to pathological adipogenesis
Abstract
This commentary proposes a mechanism for why murine diabetic adipose tissue contains very few remaining stem cells compared with normal adipose tissue. The mechanism involves the diversion of stem cells to pathological adipocytes when they divide in hyperglycemia.
Comment on
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Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations.Stem Cell Res Ther. 2014 Jun 18;5(3):79. doi: 10.1186/scrt468. Stem Cell Res Ther. 2014. PMID: 24943716 Free PMC article.
References
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- Rennart RC, Sorkin M, Januszyk M, Duscher D, Kosaraju R, Chung MT, Lennon J, Radiya-Dixit A, Raghvendra S, Maan ZN, Hu MS, Rajadas J, Rodrigues M, Gurtner GC. Diabetes impairs the angiogenic potential of adipose derived stem cells by selectively depleting cellular subpopulations. Stem Cell Res Ther. 2014;5:79. doi: 10.1186/scrt468. - DOI - PMC - PubMed
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