Oncostatin m modulation of lipid storage

doi:10.3390/biology4010151

Review

. 2015 Feb 13;4(1):151-60.

doi: 10.3390/biology4010151.

Oncostatin m modulation of lipid storage

Carrie M Elks¹, Jacqueline M Stephens^{2

3}

Affiliations

¹ Adipocyte Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. carrie.elks@pbrc.edu.
² Adipocyte Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. jsteph1@lsu.edu.
³ Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA. jsteph1@lsu.edu.

PMID: 25689119
PMCID: PMC4381222
DOI: 10.3390/biology4010151

Review

Oncostatin m modulation of lipid storage

Carrie M Elks et al. Biology (Basel). 2015.

. 2015 Feb 13;4(1):151-60.

doi: 10.3390/biology4010151.

Authors

Carrie M Elks¹, Jacqueline M Stephens^{2

3}

Affiliations

¹ Adipocyte Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. carrie.elks@pbrc.edu.
² Adipocyte Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. jsteph1@lsu.edu.
³ Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA. jsteph1@lsu.edu.

PMID: 25689119
PMCID: PMC4381222
DOI: 10.3390/biology4010151

Abstract

Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory mechanisms influencing several metabolic and biological functions of insulin-sensitive tissues. In this review, the actions of OSM in adipose tissue and liver are discussed, with an emphasis on lipid metabolism.

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Figures

**Figure 1**
Oncostatin M (OSM) is produced in adipose tissue and liver immune cells and acts in a paracrine manner in these insulin-sensitive tissues. OSM is produced in T cells and macrophages that are found in adipose tissue and are elevated in conditions of obesity/insulin resistance. OSM receptors are present on preadipocytes and adipocytes, but not macrophages. It is well-known that OSM inhibits adipocyte differentiation. In addition, OSM acts on adipocytes to induce IL-6 and PAI-1 production. These abilities of OSM suggest that blocking OSM receptor activity in preadipocytes and adipocytes may be metabolically beneficial. In liver, OSM is produced in Kupffer cells (resident macrophages) and acts in a paracrine manner on hepatocytes to decrease insulin sensitivity and increase liver lipid accumulation.

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References

1. Fasnacht N., Muller W. Conditional gp130 deficient mouse mutants. Semin. Cell Dev. Biol. 2008;19:379–384. doi: 10.1016/j.semcdb.2008.07.001. - DOI - PubMed
1. Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 2003;374:1–20. doi: 10.1042/BJ20030407. - DOI - PMC - PubMed
1. Celik A., Sahin S., Koc F., Karayakali M., Sahin M., Benli I., Kadi H., Burucu T., Ceyhan K., Erkorkmaz U., et al. Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure. Med. Sci. Monit. 2012;18:CR25–CR31. - PMC - PubMed
1. Hansen D., Dendale P., Beelen M., Jonkers R.A., Mullens A., Corluy L., Meeusen R., van Loon L.J. Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients. Eur. J. Appl. Physiol. 2010;109:397–404. doi: 10.1007/s00421-010-1362-5. - DOI - PMC - PubMed
1. Kern P.A., Ranganathan S., Li C., Wood L., Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2001;280:E745–E751. - PubMed

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[1] Fasnacht N., Muller W. Conditional gp130 deficient mouse mutants. Semin. Cell Dev. Biol. 2008;19:379–384. doi: 10.1016/j.semcdb.2008.07.001. - DOI - PubMed

[2] Fasnacht N., Muller W. Conditional gp130 deficient mouse mutants. Semin. Cell Dev. Biol. 2008;19:379–384. doi: 10.1016/j.semcdb.2008.07.001. - DOI - PubMed

[3] Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 2003;374:1–20. doi: 10.1042/BJ20030407. - DOI - PMC - PubMed

[4] Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 2003;374:1–20. doi: 10.1042/BJ20030407. - DOI - PMC - PubMed

[5] Celik A., Sahin S., Koc F., Karayakali M., Sahin M., Benli I., Kadi H., Burucu T., Ceyhan K., Erkorkmaz U., et al. Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure. Med. Sci. Monit. 2012;18:CR25–CR31. - PMC - PubMed

[6] Celik A., Sahin S., Koc F., Karayakali M., Sahin M., Benli I., Kadi H., Burucu T., Ceyhan K., Erkorkmaz U., et al. Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure. Med. Sci. Monit. 2012;18:CR25–CR31. - PMC - PubMed

[7] Hansen D., Dendale P., Beelen M., Jonkers R.A., Mullens A., Corluy L., Meeusen R., van Loon L.J. Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients. Eur. J. Appl. Physiol. 2010;109:397–404. doi: 10.1007/s00421-010-1362-5. - DOI - PMC - PubMed

[8] Hansen D., Dendale P., Beelen M., Jonkers R.A., Mullens A., Corluy L., Meeusen R., van Loon L.J. Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients. Eur. J. Appl. Physiol. 2010;109:397–404. doi: 10.1007/s00421-010-1362-5. - DOI - PMC - PubMed

[9] Kern P.A., Ranganathan S., Li C., Wood L., Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2001;280:E745–E751. - PubMed

[10] Kern P.A., Ranganathan S., Li C., Wood L., Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2001;280:E745–E751. - PubMed

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Oncostatin m modulation of lipid storage

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Oncostatin m modulation of lipid storage

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