Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants

Abstract

Prenatal maternal depression is associated with alterations in the neonatal amygdala microstructure, shedding light on the timing for the influence of prenatal maternal depression on the brain structure of the offspring. This study aimed to examine the association between prenatal maternal depressive symptomatology and infant amygdala functional connectivity and to thus establish the neural functional basis for the transgenerational transmission of vulnerability for affective disorders during prenatal development. Twenty-four infants were included in this study with both structural magnetic resonance imaging (MRI) and resting-state functional MRI (fMRI) at 6 months of age. Maternal depression was assessed at 26 weeks of gestation and 3 months after delivery using the Edinburgh Postnatal Depression Scale. Linear regression was used to identify the amygdala functional networks and to examine the associations between prenatal maternal depressive symptoms and amygdala functional connectivity. Our results showed that at 6 months of age, the amygdala is functionally connected to widespread brain regions, forming the emotional regulation, sensory and perceptual, and emotional memory networks. After controlling for postnatal maternal depressive symptoms, infants born to mothers with higher prenatal maternal depressive symptoms showed greater functional connectivity of the amygdala with the left temporal cortex and insula, as well as the bilateral anterior cingulate, medial orbitofrontal and ventromedial prefrontal cortices, which are largely consistent with patterns of connectivity observed in adolescents and adults with major depressive disorder. Our study provides novel evidence that prenatal maternal depressive symptomatology alters the amygdala's functional connectivity in early postnatal life, which reveals that the neuroimaging correlates of the familial transmission of phenotypes associated with maternal mood are apparent in infants at 6 months of age.

Figure 1

The amygdala functional networks. (a) left amygdala functional networks; (b) right amygdala functional networks; (c) amygdala functional networks. ACC, anterior cingulate cortex; AG, angular gyrus; Amyg, amygdala; antCereb, anterior cerebellum; BG, basal ganglia; dlPFC, dorsolateral prefrontal cortex; EC, entorhinal cortex; Hipp, hippocampus; lOFC, lateral orbitofrontal cortex; ITC, inferior temporal cortex; L, left; LG, lingual gyrus; LOC, lateral occipital cortex; mOFC, medial orbitofrontal cortex; MTC, middle temporal cortex; PHG, parahippocampus; PoCG, postcentral gyrus; PrCG, precentral gyrus; R, right; SMG, supramarginal gyrus; STC, superior temporal cortex; vlPFC, ventrolateral prefrontal cortex; vmPFC, ventromedial prefrontal cortex.

Figure 2

The association between prenatal maternal depression and amygdala functional networks. ACC, anterior cingulate cortex; EC, entorhinal cortex; ITC, inferior temporal cortex; L, left; mOFC, medial orbitofrontal cortex; MTC, middle temporal cortex; R, right; STC, superior temporal cortex; vmPFC, ventromedial prefrontal cortex.