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Review
. 2015 Mar;17(3):431.
doi: 10.1007/s11912-014-0431-z.

Metaplastic breast cancer: clinical overview and molecular aberrations for potential targeted therapy

Sausan Abouharb  1 , Stacy Moulder
Affiliations
Review

Metaplastic breast cancer: clinical overview and molecular aberrations for potential targeted therapy

Sausan Abouharb et al. Curr Oncol Rep. 2015 Mar.

Abstract

Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared to patients with standard invasive ductal carcinoma. Limited data are available in regards to best treatment modalities, including chemotherapy. This review gives an overview of metaplastic breast cancer and its clinical and pathologic characteristics, in addition to treatment strategies, clinical trials, and future directions.

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