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. 2015 May;59(5):2909-13.
doi: 10.1128/AAC.04763-14. Epub 2015 Feb 17.

Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Yi-Hsiang Cheng  1 , Tzu-Lung Lin  1 , Yi-Jiun Pan  1 , Yu-Ping Wang  2 , Yi-Tsung Lin  2 , Jin-Town Wang  3
Affiliations

Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Yi-Hsiang Cheng et al. Antimicrob Agents Chemother. 2015 May.

Abstract

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

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Figures

FIG 1
FIG 1
IS inserted sites and mutations in MgrB were found in this study. In the alignment with sequences of the NTUH-K2044 strain, the open triangle indicates the target sites of IS10R, and the closed triangle indicates the target sites of IS5-like elements. The nucleotides in the open box represent the amino acid changes Cys28Tyr and Stop48Tyr of MgrB. The start codon of MgrB is in bold.
See this image and copyright information in PMC

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