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Comment
. 2015 Mar 3;112(9):2635-6.
doi: 10.1073/pnas.1500054112. Epub 2015 Feb 17.

Balancing copy number in ribosomal DNA

John H Malone  1
Affiliations
Comment

Balancing copy number in ribosomal DNA

John H Malone. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The mammalian ribosome is composed of a large subunit (60S) and a small subunit (40S) that are composed of a diverse set of proteins and transcriptional arrays of noncoding RNA loci (A). Gibbons et al. (3) discovered that CNV is coupled among transcriptional units at the DNA level, suggesting a new mechanism to achieve balance of the ribosome (B).
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References

    1. Birchler JA, Veitia RA. The gene balance hypothesis: Dosage effects in plants. Methods Mol Biol. 2014;1112:25–32. - PubMed
    1. Birchler JA, Veitia RA. Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines. Proc Natl Acad Sci USA. 2012;109(37):14746–14753. - PMC - PubMed
    1. Gibbons JG, Branco AT, Godinho SA, Yu S, Lemos B. Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Proc Natl Acad Sci USA. 2015;112(8):2485–2490. - PMC - PubMed
    1. Fatica A, Tollervey D. Making ribosomes. Curr Opin Cell Biol. 2002;14(3):313–318. - PubMed
    1. Mager WH. Control of ribosomal protein gene expression. Biochim Biophys Acta. 1988;949(1):1–15. - PubMed

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